Orciprenaline sulfate

CAS No. 5874-97-5

Orciprenaline sulfate( dl-Metaproterenol | dl-Orciprenaline )

Catalog No. M15165 CAS No. 5874-97-5

A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
50MG 42 In Stock
100MG 76 In Stock
200MG 104 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Orciprenaline sulfate
  • Note
    Research use only, not for human use.
  • Brief Description
    A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.
  • Description
    A beta-2 adrenergic agonist used in the treatment of asthma and bronchial spasm.(In Vitro):Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.(In Vivo):Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
  • In Vitro
    Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages. Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to down regulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages. Western Blot Analysis Cell Line:THP-1 cells and bone marrow macrophages Concentration:10 μM Incubation Time:74 hoursResult:Enhanced β-arrestin2 and its interaction with IκBα.RT-PCR Cell Line:THP-1 cells and bone marrow macrophages Concentration:10 μM Incubation Time:74 hours Result:Led to downregulation of NF-κB.
  • In Vivo
    Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
  • Synonyms
    dl-Metaproterenol | dl-Orciprenaline
  • Pathway
    Endocrinology/Hormones
  • Target
    Adrenergic Receptor
  • Recptor
    β-adrenergic receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    5874-97-5
  • Formula Weight
    260.3
  • Molecular Formula
    C11H17NO3·0·5H2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    OC1=CC(OS(=O)(O)=O)=CC(C(O)CNC(C)C)=C1
  • Chemical Name
    3-hydroxy-5-(1-hydroxy-2-(isopropylamino)ethyl)phenyl hydrogen sulfate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kimura M, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):171-80.
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